Cell Movements and Mechanical Force Distribution During the Migration of Dictyostelium Slugs

Migration and thermotaxis of dictyostelium discoideum slugs, a model study

Dictyostelium discoideum slugs show a pronounced thermotaxis. We have modelled the motion of the D. discoideum slug in the absence and in the presence of a thermal gradient. Our model is an extension of the hybrid cellular automata/partial differential equation model, as formulated by Savill and Hogeweg [J. theor. Biol., (1997) 184, 229-235]. The modelled slugs maintain their shape and crawl, w...

Phototaxis of Dictyostelium discoideum Slugs

Cell patterning in migrating slugs of Dictyostelium discoideum.

When front quarters of migrating slugs of Dictyostelium discoideum are isolated by surgery and induced to friut immediately they produce fruiting bodies with disproportionately large stalks (Raper, 1940). The data in this communication show that the 'stalky' character of fruits derived from front quarters persists even if the cells of the front quarter are disaggregated and hence to reaggregate...

Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration

At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct “leader” phenotype with characteristic morphology and motility. However, the factors driving leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here, we use single cell gene expression analysi...

Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration.

At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct 'leader' phenotype with characteristic morphology and motility. However, the factors driving the leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here we use single-cell gene expression anal...